Coretag Therapeutics

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The platform technology of Coretag provides new groundbreaking possible options for the treatment of solid tumors and metastases, in cases where the solid tumor cannot be resected or in case there is no effective therapy available.

Coretag Therapeutics aims to start with the development two therapeutic medicines and make these treatments available for the patient as soon as possible.

Our pipeline currently consists of Actinocore and Thermcore:

Targeted treatment of solid tumors and metastases from the necrotic core with a radioactive molecule which irradiation kills living cancer cells surrounding the necrotic cores.

Actinocore is a targeted brachytherapy directly from the necrotic core inside solid tumors and metastases. Actinocore is formed by the necrosis tracer labelled with the radioactive Lutetium-177 for treatment of solid tumors and metastases. Within 12 hours after administration the necrosis tracer has bound to the necrotic core of the solid tumor and metastase and the rest of the non-bounded necrosis tracer is cleared through the kidneys. In the following days the irradiation of the Lutetium-177 kills the living tumor cells surrounding the necrotic core within a range of app. 5mm.

Treatment by labelling of our NC-Tracer with a radioactive label:

Targeted treatment of solid tumors and metastases from the necrotic core with a iron molecule which is heated up by a MRI imaging device for killing living cancer cells surrounding the necrotic cores.

Thermcore is a targeted treatment directly from inside the necrotic core of solid tumors and metastases.  Thermocre is formed by the necrosis tracer labelled with a non-radioactive iron molecule, like gadolinium. Within 12 hours after administration the necrosis tracer has bound to the necrotic core of the solid tumor or metastase. Then the iron molecule is heated up by a MRI-scan induced magnetic field. The heat kills the living tumor cells surrounding the necrotic core.

Thermcore is labelled with an iron molecule (non-radioactive):